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Integrative genomics identifies novel associations with APOL1 risk genotype in African American NEPTUNE subjects

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series. This dataset is part of the TransQST collection.

ORGANISM(S): Homo sapiens

SUBMITTER: Matthew Sampson

PROVIDER: E-GEOD-68127 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Integrative Genomics Identifies Novel Associations with APOL1 Risk Genotypes in Black NEPTUNE Subjects.

Sampson Matthew G MG Robertson Catherine C CC Martini Sebastian S Mariani Laura H LH Lemley Kevin V KV Gillies Christopher E CE Otto Edgar A EA Kopp Jeffrey B JB Randolph Anne A Vega-Warner Virginia V Eichinger Felix F Nair Viji V Gipson Debbie S DS Cattran Daniel C DC Johnstone Duncan B DB O'Toole John F JF Bagnasco Serena M SM Song Peter X PX Barisoni Laura L Troost Jonathan P JP Kretzler Matthias M Sedor John R JR

Journal of the American Society of Nephrology : JASN 20150706 3

APOL1 variants have been associated with renal phenotypes in blacks. To refine clinical outcomes and discover mechanisms of APOL1-associated kidney injury, we analyzed clinical and genomic datasets derived from 90 black subjects in the Nephrotic Syndrome Study Network (NEPTUNE), stratified by APOL1 risk genotype. Ninety subjects with proteinuria ≥0.5 g/d were enrolled at first biopsy for primary nephrotic syndrome and followed. Clinical outcomes were determined, and renal histomorphometry and se ...[more]

PMID: 26150607

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Integrative genomics identifies novel associations with APOL1 risk genotype in African American NEPTUNE subjects

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2015-07-15 | GSE68127 | GEO

Integrative genomics identifies novel associations with APOL1 risk genotype in African American NEPTUNE subjects [tubulointerstitium]

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Integrative genomics identifies novel associations with APOL1 risk genotype in African American NEPTUNE subjects [glomerulus]

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African American hepatocyte genotype

Project description:African American hepatocyte genotype

| PRJNA615863 | ENA

Integrative genomics identifies novel associations with APOL1 risk genotype in African American NEPTUNE subjects

Project description:Integrative genomics identifies novel associations with APOL1 risk genotype in African American NEPTUNE subjects

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Associations between race, APOE genotype, cognition, and mortality among urban middle-aged white and African American adults.

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