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Systems analysis of uterine microenvironment 4, 6, 8, 10, 11 or 12 days after fertilization

ABSTRACT: Analysis of uterine microenvironment at gene expression level. The hypothesis tested in the present study was that Tregs orchestrated the immune reponse triggered in presence of embryo Total RNA obtained from uterine microenvironment tissues (4, 6, 8, 10, 11 or 12 days after fertilization) compared to control tissues (uterus from non pregnant mice).

ORGANISM(S): Mus musculus

SUBMITTER: Djamel NEHAR-BELAID

PROVIDER: E-GEOD-68433 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Regulatory T Cells Orchestrate Similar Immune Evasion of Fetuses and Tumors in Mice.

Nehar-Belaid Djamel D Courau Tristan T Dérian Nicolas N Florez Laura L Ruocco Maria Grazia MG Klatzmann David D

Journal of immunology (Baltimore, Md. : 1950) 20151207 2

Embryos and tumors are both masses of dividing cells expressing foreign Ags, but they are not rejected by the immune system. We hypothesized that similar tolerogenic mechanisms prevent their rejection. Global comparison of fetal and tumor microenvironments through transcriptomics in mice revealed strikingly similar and dramatic decreases in expression of numerous immune-related pathways, including Ag presentation and T cell signaling. Unsupervised analyses highlighted the parallel kinetics and s ...[more]

PMID: 26643476

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