ATF4 Licenses C/EBPb Activity in Human Mesenchymal Stem Cells Primed for Adipogenesis
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Daniel Cohen
PROVIDER: E-GEOD-68864 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
ATF4 licenses C/EBPβ activity in human mesenchymal stem cells primed for adipogenesis.
Cohen Daniel M DM Won Kyoung-Jae KJ Nguyen Nha N Lazar Mitchell A MA Chen Christopher S CS Steger David J DJ
eLife 20150625
A well-established cascade of transcription factor (TF) activity orchestrates adipogenesis in response to chemical cues, yet how cell-intrinsic determinants of differentiation such as cell shape and/or seeding density inform this transcriptional program remain enigmatic. Here, we uncover a novel mechanism licensing transcription in human mesenchymal stem cells (hMSCs) adipogenically primed by confluence. Prior to adipogenesis, confluency promotes heterodimer recruitment of the bZip TFs C/EBPβ an ...[more]
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