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Microarray expression profile analysis of circular RNAs in human pancreatic ductal adenocarcinoma

ABSTRACT: To explore the potential involvement of circular RNAs (circRNAs) in pancreatic ductal adenocarcinoma (PDAC) oncogenesis, we conducted circRNA profiling in six pairs of human PDAC and adjacent normal tissue by microarray. Our results showed that clusters of circRNAs were aberrantly expressed in PDAC compared with normal samples, and provided potential targets for future treatment of PDAC and novel insights into PDAC biology. Analyze circular RNA expression in pancreatic ductal adenocarcinoma (PDAC) by microarray platform.

ORGANISM(S): Homo sapiens

SUBMITTER: Shibin Qu

PROVIDER: E-GEOD-69362 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Microarray expression profile of circular RNAs in human pancreatic ductal adenocarcinoma.

Qu Shibin S Song Wenjie W Yang Xisheng X Wang Jianlin J Zhang Ruohan R Zhang Zhuochao Z Zhang Hongtao H Li Haimin H

Genomics data 20150721

Pancreatic ductal adenocarcinoma (PDAC) remains a common and deadly cancer. Despite numerous efforts, no reliable biomarker is available for daily clinical practice. Circular RNAs (circRNAs) are an abundant, stable and conserved class of RNA molecules that exhibit tissue/developmental-stage-specific expression (Salzman et al., 2012; Jeck et al., 2013; Memczak et al., 2013). CircRNAs play a crucial role in disease, especially in cancer, and provide new potential diagnostic and therapeutic targets ...[more]

PMID: 26484292

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