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Development of lncRNA and Mrna expression signatures for pancreatic ductal adenocarcinoma

ABSTRACT: To further development of our lncRNA and mRNA expression approach to pancreatic ductal adenocarcinoma(PDAC), we have employed lncRNA and mRNA microarray expression profiling as a discovery platform to identify lncRNA and mRNA expression in pancreatic ductal adenocarcinoma.Human pancreatic ductal adenocarcinoma tissues and normal pancreatic tissues from PDAC donors and other duodenum diseases donors. analyze mRNA and lncRNA expression in pancreatic ductal adenocarcinoma (PDAC) by microarray platform

ORGANISM(S): Homo sapiens

SUBMITTER: yong sun

PROVIDER: E-GEOD-57144 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A novel long non-coding RNA ENST00000480739 suppresses tumour cell invasion by regulating OS-9 and HIF-1α in pancreatic ductal adenocarcinoma.

Sun Y-W YW Chen Y-F YF Li J J Huo Y-M YM Liu D-J DJ Hua R R Zhang J-F JF Liu W W Yang J-Y JY Fu X-L XL Yan T T Hong J J Cao H H

British journal of cancer 20141014 11

<h4>Background</h4>Invasion and metastasis are the distinct biologic characteristics of cancer, resulting in an exceptionally low 5-year survival rate in pancreatic ductal adenocarcinoma (PDAC). Understanding in detail the mechanisms underlying PDAC metastasis is critical for prevention and effective interventions. Long non-coding RNAs (lncRNAs) have been documented as having a critical role in cancer development and progression.<h4>Methods</h4>We examined the expression levels of lncRNA ENST000 ...[more]

PMID: 25314054

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Development of lncRNA and Mrna expression signatures for pancreatic ductal adenocarcinoma

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