Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Masahiro Ono
PROVIDER: E-GEOD-6939 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Ono Masahiro M Yaguchi Hiroko H Ohkura Naganari N Kitabayashi Issay I Nagamura Yuko Y Nomura Takashi T Miyachi Yoshiki Y Tsukada Toshihiko T Sakaguchi Shimon S
Nature 20070321 7136
Naturally arising CD25+CD4+ regulatory T cells (T(R) cells) are engaged in the maintenance of immunological self-tolerance and immune homeostasis by suppressing aberrant or excessive immune responses, such as autoimmune disease and allergy. T(R) cells specifically express the transcription factor Foxp3, a key regulator of T(R)-cell development and function. Ectopic expression of Foxp3 in conventional T cells is indeed sufficient to confer suppressive activity, repress the production of cytokines ...[more]