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Effect of MEG3 on p53 target genes in hepatoma cells

ABSTRACT: Maternally Expressed Gene 3 (MEG3) encodes a lncRNA which is suggested to function as a tumor suppressor. MEG3 functions as a tumor suppressor in hepatoma cells, whose action is mediated by interaction with p53 protein to activate p53-mediated transcriptional activity and influence the expression of partial p53 target genes. Total RNA was isolated from hepatoma cells (HepG2 and SK-Hep-1) transfected with either control or MEG3 overexpression/knockdown constructs for global expression analysis.

ORGANISM(S): Homo sapiens

SUBMITTER: Juanjuan Zhu

PROVIDER: E-GEOD-69916 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Effect of MEG3 on p53 target genes in hepatoma cells

Project description:Maternally Expressed Gene 3 (MEG3) encodes a lncRNA which is suggested to function as a tumor suppressor. MEG3 functions as a tumor suppressor in hepatoma cells, whose action is mediated by interaction with p53 protein to activate p53-mediated transcriptional activity and influence the expression of partial p53 target genes.

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Project description:Effect of MEG3 on p53 target genes in hepatoma cells

| PRJNA287128 | ENA

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