Unknown,Transcriptomics,Genomics,Proteomics

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Genome-wide analysis of the genetic regulation of gene expression in human neutrophils

ABSTRACT: Here we report an expression dataset of isolated neutrophils from 114 healthy individuals of Chinese ethnicity collected in Singapore. A total of 114 individuals with no case control stratification.

ORGANISM(S): Homo sapiens

SUBMITTER: Bernett Lee 

PROVIDER: E-GEOD-70044 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Neutrophils are an abundant immune cell type involved in both antimicrobial defence and autoimmunity. The regulation of their gene expression, however, is still largely unknown. Here we report an eQTL study on isolated neutrophils from 114 healthy individuals of Chinese ethnicity, identifying 21,210 eQTLs on 832 unique genes. Unsupervised clustering analysis of these eQTLs confirms their role in inflammatory responses and immunological diseases but also indicates strong involvement in dermatolog  ...[more]

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