Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: kathie walters
PROVIDER: E-GEOD-70445 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Walters Kathie-Anne KA D'Agnillo Felice F Sheng Zong-Mei ZM Kindrachuk Jason J Schwartzman Louis M LM Kuestner Rolf E RE Chertow Daniel S DS Golding Basil T BT Taubenberger Jeffery K JK Kash John C JC
The Journal of pathology 20151014 1
To study bacterial co-infection following 1918 H1N1 influenza virus infection, mice were inoculated with the 1918 influenza virus, followed by Streptococcus pneumoniae (SP) 72 h later. Co-infected mice exhibited markedly more severe disease, shortened survival time and more severe lung pathology, including widespread thrombi. Transcriptional profiling revealed activation of coagulation only in co-infected mice, consistent with the extensive thrombogenesis observed. Immunohistochemistry showed ex ...[more]