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Role of the histone demethylase KDM2B in hematopoietic homeostasis and malignancies

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Alexandros Tzatsos

PROVIDER: E-GEOD-70729 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Histone demethylase KDM2B regulates lineage commitment in normal and malignant hematopoiesis.

Andricovich Jaclyn J Kai Yan Y Peng Weiqun W Foudi Adlen A Tzatsos Alexandros A

The Journal of clinical investigation 20160125 3

The development of the hematopoietic system is a dynamic process that is controlled by the interplay between transcriptional and epigenetic networks to determine cellular identity. These networks are critical for lineage specification and are frequently dysregulated in leukemias. Here, we identified histone demethylase KDM2B as a critical regulator of definitive hematopoiesis and lineage commitment of murine hematopoietic stem and progenitor cells (HSPCs). RNA sequencing of Kdm2b-null HSPCs and ...[more]

PMID: 26808549

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