Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Joanna Wysocka
PROVIDER: E-GEOD-70751 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Prescott Sara L SL Srinivasan Rajini R Marchetto Maria Carolina MC Grishina Irina I Narvaiza Iñigo I Selleri Licia L Gage Fred H FH Swigut Tomek T Wysocka Joanna J
Cell 20150910 1
cis-regulatory changes play a central role in morphological divergence, yet the regulatory principles underlying emergence of human traits remain poorly understood. Here, we use epigenomic profiling from human and chimpanzee cranial neural crest cells to systematically and quantitatively annotate divergence of craniofacial cis-regulatory landscapes. Epigenomic divergence is often attributable to genetic variation within TF motifs at orthologous enhancers, with a novel motif being most predictive ...[more]