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MiR-26 dampens IL-6 production by down-regulating TNF-a/NF-kB signaling through silencing HMGA1 and MALT1 and not by directly targeting IL-6 mRNA

ABSTRACT: We found NF-kB signaling as a major target of miR-26 based on an analysis of the changes in gene activation by TNF-a in response to alteration of miR-26 levels. Transcriptional profiling of genes in response to either a miR-26 mimic or miR-26 antagomir.

ORGANISM(S): Homo sapiens

SUBMITTER: Jeffrey Chang

PROVIDER: E-GEOD-70831 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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MiR-26 down-regulates TNF-α/NF-κB signalling and IL-6 expression by silencing HMGA1 and MALT1.

Chen Chyi-Ying A CY Chang Jeffrey T JT Ho Yi-Fang YF Shyu Ann-Bin AB

Nucleic acids research 20160328 8

MiR-26 has emerged as a key tumour suppressor in various cancers. Accumulating evidence supports that miR-26 regulates inflammation and tumourigenicity largely through down-regulating IL-6 production, but the underlying mechanism remains obscure. Here, combining a transcriptome-wide approach with manipulation of cellular miR-26 levels, we showed that instead of directly targeting IL-6 mRNA for gene silencing, miR-26 diminishes IL-6 transcription activated by TNF-α through silencing NF-κB signall ...[more]

PMID: 27025651

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