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Transcription profiling of mouse liver to identify hepatic genes differentially expressed in the presence of the maslinic acid in olive oil

ABSTRACT: Two olive oils only differing in the presence of maslinic acid were prepared. Using DNA microarrays, hepatic gene expression was analysed in apoE-deficient mice with a C57BL/6J genetic background Experiment Overall Design: The experimental animals were 12, two-month old, female, homozygous apoE KO mice with a C57BL/6J genetic background. Experiment Overall Design: Two study groups were established: a) one received a chow diet (Teklad Mouse/Rat Diet no. 2014, Harlan Teklad, Harlan Ibérica, Barcelona, Spain) supplemented with 10% (w/w) olive oil (diet OO) (n=6), and b) the other received the same chow diet but supplemented with 10% (w/w) maslinic acid- enriched olive oil (diet MAOO; n= 6 and).

ORGANISM(S): Mus musculus

SUBMITTER: Jesus Osada 

PROVIDER: E-GEOD-7091 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Apolipoprotein E determines the hepatic transcriptional profile of dietary maslinic acid in mice.

Guillen Natalia N   Acín Sergio S   Surra Joaquín C JC   Arnal Carmen C   Godino Javier J   García-Granados Andrés A   Muniesa Pedro P   Ruiz-Gutiérrez Valentina V   Osada Jesús J  

The Journal of nutritional biochemistry 20081106 11

The hypothesis that the maslinic acid (MA) of olive oil (OO) dramatically influences hepatic gene expression was tested in mice. Two OOs only differing in the presence of MA were prepared. Using DNA microarrays, we analyzed hepatic gene expression in apolipoprotein E (apoE)-deficient mice with a C57BL/6J genetic background that were fed with isocaloric, isonitrogenous diets containing either 10% (w/w) OO or 10% MA-enriched OO. As an initial screening of potential candidate genes involved in a di  ...[more]

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