Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Xiaoqiang Xu
PROVIDER: E-GEOD-7101 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
McNeely Samuel C SC Xu Xiaogiang X Taylor B Frazier BF Zacharias Wolfgang W McCabe Michael J MJ States J Christopher JC
Environmental health perspectives 20060901 9
<h4>Background</h4>Arsenic is both a human carcinogen and a chemotherapeutic agent, but the mechanism of neither arsenic-induced carcinogenesis nor tumor selective cytotoxicity is clear. Using a model cell line in which p53 expression is regulated exogenously in a tetracycline-off system (TR9-7 cells) , our laboratory has shown that arsenite disrupts mitosis and that p53-deficient cells [p53(-)], in contrast to p53-expressing cells [p53(+)], display greater sensitivity to arsenite-induced mitoti ...[more]