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Influence of human P53 on plant gene expression

ABSTRACT: Mammalian p53 is a super tumor suppressor and plays a key role in guarding genome from DNA damage. However, p53 has not been found in plants which do not bear cancer although they constantly expose to ionizing radiation of ultraviolet light. Here we introduced p53 into the model plant Arabidopsis and examined p53-conferred phenotype in plant. Most strikingly, p53 caused early senescence and fasciation. We used microarrays to identify differentially expressed genes 10-day-old wild type (Col-0) and 35S:P53-transgenic plants. Replicates are derived from three independent biological experiments.

ORGANISM(S): Arabidopsis thaliana

SUBMITTER: Shui Wang

PROVIDER: E-GEOD-79678 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Influence of Human p53 on Plant Development.

Ma Huimin H Song Teng T Wang Tianhua T Wang Shui S

PloS one 20160920 9

Mammalian p53 is a super tumor suppressor and plays a key role in guarding genome from DNA damage. However, p53 has not been found in plants which do not bear cancer although they constantly expose to ionizing radiation of ultraviolet light. Here we introduced p53 into the model plant Arabidopsis and examined p53-conferred phenotype in plant. Most strikingly, p53 caused early senescence and fasciation. In plants, fasciation has been shown as a result of the elevated homologous DNA recombination. ...[more]

PMID: 27648563

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