Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Susan Gray
PROVIDER: E-GEOD-7137 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cell metabolism 20070401 4
In the postabsorptive state, certain tissues, including the brain, require glucose as the sole source of energy. After an overnight fast, hepatic glycogen stores are depleted, and gluconeogenesis becomes essential for preventing life-threatening hypoglycemia. Mice with a targeted deletion of KLF15, a member of the Krüppel-like family of transcription factors, display severe hypoglycemia after an overnight (18 hr) fast. We provide evidence that defective amino acid catabolism promotes the develop ...[more]