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Transcription profiling of human peripheral blood leukocytes from CHASRS particpants

ABSTRACT: Gene expression profiling was carried out on peripheral blood leukocytes from 14 healthy older adults. The primary research question is whether gene expression differs in individuals experiencing chronically high levels of social isolation (by UCLA Loneliness Scale) vs chronically low levels of social isolation. Experiment Overall Design: Gene expression profiling was carried out on peripheral blood leukocytes from 14 healthy older adults. The primary research question is whether gene expression differs in individuals experiencing chronically high levels of social isolation (by UCLA Loneliness Scale) vs chronically low levels of social isolation.

ORGANISM(S): Homo sapiens

SUBMITTER: Steve Cole

PROVIDER: E-GEOD-7148 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Social regulation of gene expression in human leukocytes.

Cole Steve W SW Hawkley Louise C LC Arevalo Jesusa M JM Sung Caroline Y CY Rose Robert M RM Cacioppo John T JT

Genome biology 20070101 9

<h4>Background</h4>Social environmental influences on human health are well established in the epidemiology literature, but their functional genomic mechanisms are unclear. The present study analyzed genome-wide transcriptional activity in people who chronically experienced high versus low levels of subjective social isolation (loneliness) to assess alterations in the activity of transcription control pathways that might contribute to increased adverse health outcomes in social isolates.<h4>Resu ...[more]

PMID: 17854483

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