Gene expression profiling of retrovirus PDGFB induced Glioma in control and Olig2cKO tumor
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Richard Lu
PROVIDER: E-GEOD-71493 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Olig2-Dependent Reciprocal Shift in PDGF and EGF Receptor Signaling Regulates Tumor Phenotype and Mitotic Growth in Malignant Glioma.
Lu Fanghui F Chen Ying Y Zhao Chuntao C Wang Haibo H He Danyang D Xu Lingli L Wang Jincheng J He Xuelian X Deng Yaqi Y Lu Ellen E EE Liu Xue X Verma Ravinder R Bu Hong H Drissi Rachid R Fouladi Maryam M Stemmer-Rachamimov Anat O AO Burns Dennis D Xin Mei M Rubin Joshua B JB Bahassi El Mustapha EM Canoll Peter P Holland Eric C EC Lu Q Richard QR
Cancer cell 20160501 5
Malignant gliomas exhibit extensive heterogeneity and poor prognosis. Here we identify mitotic Olig2-expressing cells as tumor-propagating cells in proneural gliomas, elimination of which blocks tumor initiation and progression. Intriguingly, deletion of Olig2 resulted in tumors that grow, albeit at a decelerated rate. Genome occupancy and expression profiling analyses reveal that Olig2 directly activates cell-proliferation machinery to promote tumorigenesis. Olig2 deletion causes a tumor phenot ...[more]
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