Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Global hepatic gene expression data from germ free and specific pathogen free male mice.

ABSTRACT: Liver clock regulates transcription of hepatic genes in response to feeding. To explore the possibility that the microbiome influences this process, we measured the liver transcriptome in normal mice (Specific Pathogen Free or SPF mice) and compared it to the transcriptome in mice lacking microbiota (Germ Free or GF mice) at different time points over 24h. We used microarrays to detail the global programme of gene expression in liver of GF and SPF 10-12 weeks-old male C57Bl/6 male mice. There are 40 liver samples, each from an individual mouse. The samples are from germ free mice (GF) and specific pathogen free mice (SPF). Mice of both types were sacrificed at four time points: Zeitgeber Time 0, 6, 12, and 18. There are five replicates per condition.

ORGANISM(S): Mus musculus

SUBMITTER: Alexandra Montagner

PROVIDER: E-GEOD-71628 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Hepatic circadian clock oscillators and nuclear receptors integrate microbiome-derived signals.

Montagner Alexandra A Korecka Agata A Polizzi Arnaud A Lippi Yannick Y Blum Yuna Y Canlet Cécile C Tremblay-Franco Marie M Gautier-Stein Amandine A Burcelin Rémy R Yen Yi-Chun YC Je Hyunsoo Shawn HS Al-Asmakh Maha M Mithieux Gilles G Arulampalam Velmurugesan V Lagarrigue Sandrine S Guillou Hervé H Pettersson Sven S Wahli Walter W

Scientific reports 20160216

The liver is a key organ of metabolic homeostasis with functions that oscillate in response to food intake. Although liver and gut microbiome crosstalk has been reported, microbiome-mediated effects on peripheral circadian clocks and their output genes are less well known. Here, we report that germ-free (GF) mice display altered daily oscillation of clock gene expression with a concomitant change in the expression of clock output regulators. Mice exposed to microbes typically exhibit characteriz ...[more]

PMID: 26879573

Dataset Information

Global hepatic gene expression data from germ free and specific pathogen free male mice.

Publications

Hepatic circadian clock oscillators and nuclear receptors integrate microbiome-derived signals.

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