Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse xenograft L2987 lung tumor tissue samples


ABSTRACT: Transcriptional profiling was conducted on RNA from 8 xenograft L2987lung tumor tissue samples to identify genes affected by treatment with a VEGFR-2 small molecule inhibitor Experiment Overall Design: Baseline and 14 days post treatement gene expression profiling was performed using 8 xenograft L2987 lung tumor tissue samples to identify genes affected by a VEGFR-2 small molecule inhibitor

ORGANISM(S): Mus musculus

SUBMITTER: Mark David Ayers 

PROVIDER: E-GEOD-7209 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Discovery and validation of biomarkers that respond to treatment with brivanib alaninate, a small-molecule VEGFR-2/FGFR-1 antagonist.

Ayers Mark M   Fargnoli Joseph J   Lewin Anne A   Wu Qiuyan Q   Platero J Suso JS  

Cancer research 20070701 14


The process of neovascularization from preexisting blood vessels, referred to as angiogenesis, plays a critical role in both tumor growth and dissemination in multiple cancer types. Currently, there exists a need to identify biomarkers that can both indicate biological activity and predict efficacy at the molecular level for antiangiogenesis drugs which are anticipated to result in tumor stasis rather than regression. To identify such biomarkers, athymic mice bearing L2987 human tumor xenografts  ...[more]

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