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Multi-scale genomic, transcriptomic and proteomic analysis of colorectal cancer cell lines to identify novel biomarkers

ABSTRACT: The objective of this study was to measure copy number alterations in a panel of 15 CRC cell lines and relate them to treatment sensitivity. Assessment of copy number variations in a panel of 15 colorectal cancer cell lines

ORGANISM(S): Homo sapiens

SUBMITTER: Romina Briffa

PROVIDER: E-GEOD-72296 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Multi-Scale Genomic, Transcriptomic and Proteomic Analysis of Colorectal Cancer Cell Lines to Identify Novel Biomarkers.

Briffa Romina R Um Inhwa I Faratian Dana D Zhou Ying Y Turnbull Arran K AK Langdon Simon P SP Harrison David J DJ

PloS one 20151217 12

Selecting colorectal cancer (CRC) patients likely to respond to therapy remains a clinical challenge. The objectives of this study were to establish which genes were differentially expressed with respect to treatment sensitivity and relate this to copy number in a panel of 15 CRC cell lines. Copy number variations of the identified genes were assessed in a cohort of CRCs. IC50's were measured for 5-fluorouracil, oxaliplatin, and BEZ-235, a PI3K/mTOR inhibitor. Cell lines were profiled using arra ...[more]

PMID: 26678268

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