Dataset Information
Transcription profiling of untreated mouse lung broncheolar lavage samples (part of wider carcinogenesis study)
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Robert Stearman
PROVIDER: E-GEOD-7269 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
A macrophage gene expression signature defines a field effect in the lung tumor microenvironment.
Cancer research 20080101 1
One area of intensive investigation is to understand complex cellular and signaling interactions in the tumor microenvironment. Using a novel, although straightforward, microarray approach, we defined a gene expression signature from the lung tumor microenvironment in the murine A/J-urethane model of human lung adenocarcinoma. The tumor microenvironment is reflected by the composition of the cell types present and alterations in mRNA levels, resulting in a "Field Effect" around the tumor. The ge ...[more]
