Unknown,Transcriptomics,Genomics,Proteomics

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Hepatic expression of Sonic Hedgehog induces liver fibrosis and promotes hepatocarcinogenesis in a transgenic mouse model


ABSTRACT: The causative role of activated Hedgehog signaling in liver fibrosis was investigated in vivo. Using hydrodynamics-based transfection, a transgenic mouse model has been developed that expresses Sonic Hedgehog (SHH), a ligand for Hedgehog signaling, in the liver. Levels of hepatic fibrosis and fibrosis-related gene expression were assessed in the model.

ORGANISM(S): Mus musculus

SUBMITTER: JUNGWOO EUN 

PROVIDER: E-GEOD-72758 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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