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Genome-wide microRNA expression induced by TNF

ABSTRACT: We sequenced microRNAs from bone marrow derived macrophages derived from the control (WT) and RBP-J conditional knockout mice (RBP-J KO; Rbpjf/f; LysM Cre). Examination of differential microRNA expression levels induced by TNF as well as regulated by RBP-J in bone marrow derived macrophages.

ORGANISM(S): Mus musculus

SUBMITTER: Baohong Zhao

PROVIDER: E-GEOD-72966 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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RBP-J-Regulated miR-182 Promotes TNF-α-Induced Osteoclastogenesis.

Miller Christine H CH Smith Sinead M SM Elguindy Mahmoud M Zhang Tuo T Xiang Jenny Z JZ Hu Xiaoyu X Ivashkiv Lionel B LB Zhao Baohong B

Journal of immunology (Baltimore, Md. : 1950) 20160509 12

Increased osteoclastogenesis is responsible for osteolysis, which is a severe consequence of inflammatory diseases associated with bone destruction, such as rheumatoid arthritis and periodontitis. The mechanisms that limit osteoclastogenesis under inflammatory conditions are largely unknown. We previously identified transcription factor RBP-J as a key negative regulator that restrains TNF-α-induced osteoclastogenesis and inflammatory bone resorption. In this study, we tested whether RBP-J suppre ...[more]

PMID: 27183593

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