Unknown,Transcriptomics,Genomics,Proteomics

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FGFR signature


ABSTRACT: Drugs that target specific gene alterations have proven beneficial in the treatment of cancer. Because cancer cells have multiple resistance mechanisms, it is important to understand the downstream pathways of the target genes and monitor the pharmacodynamic markers associated with therapeutic efficacy. We performed a transcriptome analysis to characterize the response of various cancer cell lines. We performed a transcriptome analysis to characterize the response of various cancer cell lines to a selective fibroblast growth factor receptor (FGFR) inhibitor (CH5183284/Debio 1347), a mitogen-activated protein kinase kinase (MEK) inhibitor, or a phosphoinositide 3-kinase (PI3K) inhibitor. We treated compounds for 24 hours and purified total RNA.

ORGANISM(S): Homo sapiens

SUBMITTER: Yoshito Nakanishi 

PROVIDER: E-GEOD-73024 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

ERK Signal Suppression and Sensitivity to CH5183284/Debio 1347, a Selective FGFR Inhibitor.

Nakanishi Yoshito Y   Mizuno Hideaki H   Sase Hitoshi H   Fujii Toshihiko T   Sakata Kiyoaki K   Akiyama Nukinori N   Aoki Yuko Y   Aoki Masahiro M   Ishii Nobuya N  

Molecular cancer therapeutics 20151005 12


Drugs that target specific gene alterations have proven beneficial in the treatment of cancer. Because cancer cells have multiple resistance mechanisms, it is important to understand the downstream pathways of the target genes and monitor the pharmacodynamic markers associated with therapeutic efficacy. We performed a transcriptome analysis to characterize the response of various cancer cell lines to a selective fibroblast growth factor receptor (FGFR) inhibitor (CH5183284/Debio 1347), a mitogen  ...[more]

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