Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Yoshito Nakanishi
PROVIDER: E-GEOD-73024 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Nakanishi Yoshito Y Mizuno Hideaki H Sase Hitoshi H Fujii Toshihiko T Sakata Kiyoaki K Akiyama Nukinori N Aoki Yuko Y Aoki Masahiro M Ishii Nobuya N
Molecular cancer therapeutics 20151005 12
Drugs that target specific gene alterations have proven beneficial in the treatment of cancer. Because cancer cells have multiple resistance mechanisms, it is important to understand the downstream pathways of the target genes and monitor the pharmacodynamic markers associated with therapeutic efficacy. We performed a transcriptome analysis to characterize the response of various cancer cell lines to a selective fibroblast growth factor receptor (FGFR) inhibitor (CH5183284/Debio 1347), a mitogen ...[more]