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Epigenetic regulation in the elderly over time

ABSTRACT: DNA methylation levels in whole blood measured over a ten years follow up in an elderly birth cohort of 86 samples For each sample, whole blood was drawn in year 1997 and in year 2007 Follow-up design: Same participant was measured over time in 1997 and 2007

ORGANISM(S): Homo sapiens

SUBMITTER: Qihua Tan

PROVIDER: E-GEOD-73115 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Epigenetic drift in the aging genome: a ten-year follow-up in an elderly twin cohort.

Tan Qihua Q Heijmans Bastiaan T BT Hjelmborg Jacob V B JV Soerensen Mette M Christensen Kaare K Christiansen Lene L

International journal of epidemiology 20160806 4

<h4>Background</h4>Current epigenetic studies on aging are dominated by the cross-sectional design that correlates subjects' ages or age groups with their measured epigenetic profiles. Such studies have been more aimed at age prediction or building up the epigenetic clock of age rather than focusing on the dynamic patterns in epigenetic changes during the aging process.<h4>Methods</h4>We performed an epigenome-wide association study of intra-individual longitudinal changes in DNA methylation at ...[more]

PMID: 27498152

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