Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Emodin inhibits macrophage alernative activation [Control-IL4-Emodin]


ABSTRACT: In order to fully characterize emodin's effects on macrophage alternative activation, peritoneal macrophages were stimulated with IL4 with or without emodin and gene expression was analyzed using a whole genome microarray. Emodin significantly attenuated the IL4 induced changes in a large percentage of genes (60%) through inhibiting multiple signaling pathways. RT-qPCR was used to confirm the results in several genes associated with M2 macrophage activation including: Arg1, Chi3l3, and CD206. Three-condition, one-color experiment: Vehicle control, IL4 or IL4-Emodin treated periferal WBC PMN samples: 4 biological replicates each.

ORGANISM(S): Mus musculus

SUBMITTER: Kim Creek 

PROVIDER: E-GEOD-73309 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Similar Datasets

2016-07-04 | E-GEOD-73310 | biostudies-arrayexpress
2016-07-04 | E-GEOD-73311 | biostudies-arrayexpress
2016-01-02 | GSE73309 | GEO
2014-03-05 | E-GEOD-55548 | biostudies-arrayexpress
2014-03-05 | E-GEOD-55549 | biostudies-arrayexpress
2014-03-05 | E-GEOD-55547 | biostudies-arrayexpress
2016-05-16 | E-GEOD-77819 | biostudies-arrayexpress
2016-05-16 | E-GEOD-77821 | biostudies-arrayexpress
2016-05-16 | E-GEOD-77820 | biostudies-arrayexpress
2016-05-16 | E-GEOD-77822 | biostudies-arrayexpress