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Genome-wide DNA methylation study of hip and knee osteoarthritic and healthy cartilage reveals embryonic organ and skeletal system morphogenesis as major pathways involved in osteoarthritis

ABSTRACT: Cartilage samples were collected from hip or knee joint replacement patients either due to primary OA or hip fractures as controls. DNA was extracted from the collected cartilage and assayed by Illumina Infinium HumanMethylation450 ‎BeadChip array, which allows for the analysis of >480,000 CpG sites. Bisulphite converted DNA from 5 hip osteoarthritic, 6 knee osteoarthritic and 7 hip healhty cartilage samples were hybridised to the Illumina Infinium HumanMethylation450 ‎BeadChip array

ORGANISM(S): Homo sapiens

SUBMITTER: Guangju Zhai 

PROVIDER: E-GEOD-73626 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genome-wide DNA methylation study of hip and knee cartilage reveals embryonic organ and skeletal system morphogenesis as major pathways involved in osteoarthritis.

Aref-Eshghi Erfan E   Zhang Yuhua Y   Liu Ming M   Harper Patricia E PE   Martin Glynn G   Furey Andrew A   Green Roger R   Sun Guang G   Rahman Proton P   Zhai Guangju G  

BMC musculoskeletal disorders 20151009

<h4>Background</h4>Evidence suggests that epigenetics plays a role in osteoarthrits (OA). The aim of the study was to describe the genome wide DNA methylation changes in hip and knee OA and identify novel genes and pathways involved in OA by comparing the DNA methylome of the hip and knee osteoarthritic cartilage tissues with those of OA-free individuals.<h4>Methods</h4>Cartilage samples were collected from hip or knee joint replacement patients either due to primary OA or hip fractures as contr  ...[more]

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