Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human age-dichotomized ER+, N0 breast tumors reveals enhanced NF kappa B and AP-1 activity associated with antiestrogen resistant breast caner

ABSTRACT: Signaling pathways that converge on two different transcription factor complexes, NFκB and AP-1, have been identified in estrogen receptor (ER)-positive breast cancers resistant to the antiestrogen, tamoxifen. In this study, biomarkers co-ordinately up-regulated by NFKB and AP-1 with prognositic significance are identified in a largely TAM-treated set of ER+ node negative breast cancers. The prognostic value with respect to age is also investigated. Experiment Overall Design: 54 ER+ node negative breast tumors with known clinical outcome were analyzed. Genes co-ordinately regulated by NFKB and AP1from literature are identified from a significant gene set obtained through a minimum variation filter. Biomarker expression is used to dichotomize samples into high vs. low expressors to determine prognostic value

ORGANISM(S): Homo sapiens

SUBMITTER: Christina Yau 

PROVIDER: E-GEOD-7378 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Enhanced NF kappa B and AP-1 transcriptional activity associated with antiestrogen resistant breast cancer.

Zhou Yamei Y   Yau Christina C   Gray Joe W JW   Chew Karen K   Dairkee Shanaz H SH   Moore Dan H DH   Eppenberger Urs U   Eppenberger-Castori Serenella S   Benz Christopher C CC  

BMC cancer 20070403

<h4>Background</h4>Signaling pathways that converge on two different transcription factor complexes, NFkappaB and AP-1, have been identified in estrogen receptor (ER)-positive breast cancers resistant to the antiestrogen, tamoxifen.<h4>Methods</h4>Two cell line models of tamoxifen-resistant ER-positive breast cancer, MCF7/HER2 and BT474, showing increased AP-1 and NFkappaB DNA-binding and transcriptional activities, were studied to compare tamoxifen effects on NFkappaB and AP-1 regulated reporte  ...[more]

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