Transcription profiling of rat heart samples from active and sedentary animals
Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Claes Strøm
PROVIDER: E-GEOD-739 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Expression profiling reveals differences in metabolic gene expression between exercise-induced cardiac effects and maladaptive cardiac hypertrophy.
Strøm Claes C CC Aplin Mark M Ploug Thorkil T Christoffersen Tue E H TE Langfort Jozef J Viese Michael M Galbo Henrik H Haunsø Stig S Sheikh Søren P SP
The FEBS journal 20050601 11
While cardiac hypertrophy elicited by pathological stimuli eventually leads to cardiac dysfunction, exercise-induced hypertrophy does not. This suggests that a beneficial hypertrophic phenotype exists. In search of an underlying molecular substrate we used microarray technology to identify cardiac gene expression in response to exercise. Rats exercised for seven weeks on a treadmill were characterized by invasive blood pressure measurements and echocardiography. RNA was isolated from the left ve ...[more]
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