Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Transcription profiling of mouse adult cardiomyocytes treated with fractalkine (CX3CL1)


ABSTRACT: Background and Aims: It is known that inflammatory processes are activated in heart failure, but the regulation of cytokines and their role in the pathogenesis of the disease are not well understood. We have identified fractalkine as a possible novel mediator in HF development. To address this issue, we have performed microarray analysis of cardiomyocytes treated with different isoforms of fractalkine. Methods: Cardiomyocytes isolated from adult rat hearts and treated with different forms of fractalkine for 24 hours. Control cells were treated with BSA. Molecular alterations in myocardial tissue were measured by using cDNA microarrays. Molecular pathways affected were identified by the Ingenuity Pathway Analysis software. Results: Several molecular pathways were affected upon fractalkine stimulation of adult cardiomyocytes. Experiment Overall Design: Cardiomyocytes isolated from adult rat hearts at three different timepoints. Five fractalkine treated samples and five control samples were pairwise analyzed. The cells were from three different isolations. Treated and untreated cells from the same isolation were compared on each microarray.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Cathrine Husberg 

PROVIDER: E-GEOD-7397 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Similar Datasets

2008-02-01 | GSE7397 | GEO
| PRJNA97887 | ENA
2021-09-15 | GSE161555 | GEO
2011-09-30 | E-GEOD-31969 | biostudies-arrayexpress
2012-02-10 | E-GEOD-35671 | biostudies-arrayexpress
2010-06-24 | E-GEOD-17020 | biostudies-arrayexpress
2012-02-10 | E-GEOD-35673 | biostudies-arrayexpress
2020-05-27 | PXD013020 | Pride
2015-12-04 | GSE68921 | GEO
2012-02-10 | E-GEOD-35672 | biostudies-arrayexpress