Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Gerard Kaiko
PROVIDER: E-GEOD-74601 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cell 20160602 7
In the mammalian intestine, crypts of Leiberkühn house intestinal epithelial stem/progenitor cells at their base. The mammalian intestine also harbors a diverse array of microbial metabolite compounds that potentially modulate stem/progenitor cell activity. Unbiased screening identified butyrate, a prominent bacterial metabolite, as a potent inhibitor of intestinal stem/progenitor proliferation at physiologic concentrations. During homeostasis, differentiated colonocytes metabolized butyrate lik ...[more]