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Dm Snail Affymetrix ChIP

ABSTRACT: Genomewide mapping of D. melanogaster Snail protein binding during embryonic development at 2-4 hrs after egg-laying. Two independent repeats were assayed and preimmune-serum was used as a control. The enriched DNA was hybridized to high density Affymetrix GeneChip Drosophila Tiling 1.0R array

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Charles Girardot

PROVIDER: E-MTAB-1589 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A conserved role for Snail as a potentiator of active transcription.

Rembold Martina M Ciglar Lucia L Yáñez-Cuna J Omar JO Zinzen Robert P RP Girardot Charles C Jain Ankit A Welte Michael A MA Stark Alexander A Leptin Maria M Furlong Eileen E M EE

Genes & development 20140108 2

The transcription factors of the Snail family are key regulators of epithelial-mesenchymal transitions, cell morphogenesis, and tumor metastasis. Since its discovery in Drosophila ∼25 years ago, Snail has been extensively studied for its role as a transcriptional repressor. Here we demonstrate that Drosophila Snail can positively modulate transcriptional activation. By combining information on in vivo occupancy with expression profiling of hand-selected, staged snail mutant embryos, we identifie ...[more]

PMID: 24402316

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