ZFP57 recognizes multiple and closely spaced sequence motif variants to maintain repressive epigenetic marks in mouse embryonic stem cells
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ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Marco Cammisa
PROVIDER: E-GEOD-74757 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
ZFP57 recognizes multiple and closely spaced sequence motif variants to maintain repressive epigenetic marks in mouse embryonic stem cells.
Anvar Zahra Z Cammisa Marco M Riso Vincenzo V Baglivo Ilaria I Kukreja Harpreet H Sparago Angela A Girardot Michael M Lad Shraddha S De Feis Italia I Cerrato Flavia F Angelini Claudia C Feil Robert R Pedone Paolo V PV Grimaldi Giovanna G Riccio Andrea A
Nucleic acids research 20151019 3
Imprinting Control Regions (ICRs) need to maintain their parental allele-specific DNA methylation during early embryogenesis despite genome-wide demethylation and subsequent de novo methylation. ZFP57 and KAP1 are both required for maintaining the repressive DNA methylation and H3-lysine-9-trimethylation (H3K9me3) at ICRs. In vitro, ZFP57 binds a specific hexanucleotide motif that is enriched at its genomic binding sites. We now demonstrate in mouse embryonic stem cells (ESCs) that SNPs disrupti ...[more]
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