Transcriptional effects of I-PpoI induced DNA double strand breaks in mouse lymphocytes
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: David Sturgill
PROVIDER: E-GEOD-74855 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Controlled DNA double-strand break induction in mice reveals post-damage transcriptome stability.
Kim Jeongkyu J Sturgill David D Tran Andy D AD Sinclair David A DA Oberdoerffer Philipp P
Nucleic acids research 20151219 7
DNA double-strand breaks (DSBs) and their repair can cause extensive epigenetic changes. As a result, DSBs have been proposed to promote transcriptional and, ultimately, physiological dysfunction via both cell-intrinsic and cell-non-autonomous pathways. Studying the consequences of DSBs in higher organisms has, however, been hindered by a scarcity of tools for controlled DSB induction. Here, we describe a mouse model that allows for both tissue-specific and temporally controlled DSB formation at ...[more]
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