Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Kinetics of IFNa response


ABSTRACT: We describe finely resolved kinetics of the transcriptional response to IFNa in B cells in vivo. Temporal changes in expression of the most robustly induced ISGs were analyzed across 23 (15min - 15hrs) timepoints. Most ISGs reach peak induction at approximately 2hrs and generally in a synchronus manner. These analses provide insight into the regulatory network structure of IFN responses. Male C57BL/6 mice were injected subcutaneously with 10,000U IFNa according to time course profile. Splenic B cells were sorted by FACS directly into TriZol and gene expression profiling was performed on Affymetrix Mouse Gene 1.0 ST Arrays.

ORGANISM(S): Mus musculus

SUBMITTER: CBDM Lab 

PROVIDER: E-GEOD-75195 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Similar Datasets

2015-11-20 | GSE75195 | GEO
2015-11-20 | E-GEOD-75202 | biostudies-arrayexpress
2015-11-20 | E-GEOD-75194 | biostudies-arrayexpress
2016-07-20 | E-GEOD-84561 | biostudies-arrayexpress
2016-07-20 | E-GEOD-84566 | biostudies-arrayexpress
2015-11-20 | E-GEOD-75203 | biostudies-arrayexpress
2016-07-20 | GSE84561 | GEO
2016-07-20 | GSE84566 | GEO
2016-07-20 | E-GEOD-84560 | biostudies-arrayexpress
2016-07-20 | E-GEOD-84565 | biostudies-arrayexpress