Dataset Information
RNA-seq analysis of single cells of the oligodendrocyte lineage from nine distinct regions of the anterior-posterior and dorsal-ventral axis of the mouse juvenile central nervous system
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Sten Linnarsson
PROVIDER: E-GEOD-75330 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system.
Science (New York, N.Y.) 20160601 6291
Oligodendrocytes have been considered as a functionally homogeneous population in the central nervous system (CNS). We performed single-cell RNA sequencing on 5072 cells of the oligodendrocyte lineage from 10 regions of the mouse juvenile and adult CNS. Thirteen distinct populations were identified, 12 of which represent a continuum from Pdgfra(+) oligodendrocyte precursor cells (OPCs) to distinct mature oligodendrocytes. Initial stages of differentiation were similar across the juvenile CNS, wh ...[more]
