Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Ranjit Shetty
PROVIDER: E-GEOD-2437 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Shetty Ranjit S RS Bose Soma C SC Nickell Melissa D MD McIntyre Jeremy C JC Hardin Debra H DH Harris Andrew M AM McClintock Timothy S TS
Molecular and cellular neurosciences 20050901 1
The olfactory epithelium has the unusual ability to replace its neurons. We forced replacement of mouse olfactory sensory neurons by bulbectomy. Microarray, bioinformatics, and in situ hybridization techniques detected a rapid shift in favor of pro-apoptotic proteins, a progressive immune response by macrophages and dendritic cells, and identified or predicted 439 mRNAs enriched in olfactory sensory neurons, including gene silencing factors and sperm flagellar proteins. Transcripts encoding cell ...[more]