Unknown,Transcriptomics,Genomics,Proteomics

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H3K36 mutations promote sarcomagenesis through genome-wide remodeling of H3K36 and H3K27 methylation [Ring1a-1b_RNASeq]

ABSTRACT: The goal of this study is to understand the genome-wide alterations in chromatin landscapy induced by a histone mutation (H3.3 K36M) derived from chondroblastomas Examination of the transcriptome changes of Ring1a and Ring1b knockdown in mouse mesenchymal progenitor cells

ORGANISM(S): Mus musculus

SUBMITTER: Peter Lewis 

PROVIDER: E-GEOD-75854 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Several types of pediatric cancers reportedly contain high-frequency missense mutations in histone H3, yet the underlying oncogenic mechanism remains poorly characterized. Here we report that the H3 lysine 36-to-methionine (H3K36M) mutation impairs the differentiation of mesenchymal progenitor cells and generates undifferentiated sarcoma in vivo. H3K36M mutant nucleosomes inhibit the enzymatic activities of several H3K36 methyltransferases. Depleting H3K36 methyltransferases, or expressing an H3  ...[more]

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