Microarray analysis of high-dose recombinant erythropoietin treatment of unilateral brain injury in neonatal mouse hippocampus
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Richard Beyer
PROVIDER: E-GEOD-75865 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Microarray analysis of high-dose recombinant erythropoietin treatment of unilateral brain injury in neonatal mouse hippocampus.
Juul Sandra E SE Beyer Richard P RP Bammler Theo K TK McPherson Ronald J RJ Wilkerson Jasmine J Farin Federico M FM
Pediatric research 20090501 5
Recombinant human erythropoietin (rEpo) is neuroprotective in neonatal models of brain injury. Proposed mechanisms of neuroprotection include activation of gene pathways that decrease oxidative injury, inflammation, and apoptosis, while increasing vasculogenesis and neurogenesis. To determine the effects of rEpo on gene expression in 10-d-old BALB-c mice with unilateral brain injury, we compared microarrays from the hippocampi of brain-injured pups treated with saline or rEpo to similarly treate ...[more]
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