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Kinetics after JQ1 treatment in liver cancer cell

ABSTRACT: Analysis of global gene expression after BRD4 inhibition by JQ1 in liver cancer cell lines SK-Hep1 Total RNA obtained from human liver cancer cell line SK-Hep1 cells after treatment of JQ1

ORGANISM(S): Homo sapiens

SUBMITTER: JUNGWOO EUN

PROVIDER: E-GEOD-75908 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Epigenetic reader BRD4 inhibition as a therapeutic strategy to suppress E2F2-cell cycle regulation circuit in liver cancer.

Hong Seong Hwi SH Eun Jung Woo JW Choi Sung Kyung SK Shen Qingyu Q Choi Wahn Soo WS Han Jeung-Whan JW Nam Suk Woo SW You Jueng Soo JS

Oncotarget 20160501 22

Deregulation of the epigenome component affects multiple pathways in the cancer phenotype since the epigenome acts at the pinnacle of the hierarchy of gene expression. Pioneering work over the past decades has highlighted that targeting enzymes or proteins involved in the epigenetic regulation is a valuable approach to cancer therapy. Very recent results demonstrated that inhibiting the epigenetic reader BRD4 has notable efficacy in diverse cancer types. We investigated the potential of BRD4 as ...[more]

PMID: 27081696

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