Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: JUNGWOO EUN
PROVIDER: E-GEOD-75908 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Hong Seong Hwi SH Eun Jung Woo JW Choi Sung Kyung SK Shen Qingyu Q Choi Wahn Soo WS Han Jeung-Whan JW Nam Suk Woo SW You Jueng Soo JS
Oncotarget 20160501 22
Deregulation of the epigenome component affects multiple pathways in the cancer phenotype since the epigenome acts at the pinnacle of the hierarchy of gene expression. Pioneering work over the past decades has highlighted that targeting enzymes or proteins involved in the epigenetic regulation is a valuable approach to cancer therapy. Very recent results demonstrated that inhibiting the epigenetic reader BRD4 has notable efficacy in diverse cancer types. We investigated the potential of BRD4 as ...[more]