Map of DnaC localization in the presence or absence of PcrA (PcrA depletion)
Ontology highlight
ABSTRACT:
ORGANISM(S): Bacillus subtilis subsp. subtilis str. JH642
SUBMITTER: Houra Merrikh
PROVIDER: E-GEOD-75953 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
The B. subtilis Accessory Helicase PcrA Facilitates DNA Replication through Transcription Units.
Merrikh Christopher N CN Brewer Bonita J BJ Merrikh Houra H
PLoS genetics 20150612 6
In bacteria the concurrence of DNA replication and transcription leads to potentially deleterious encounters between the two machineries, which can occur in either the head-on (lagging strand genes) or co-directional (leading strand genes) orientations. These conflicts lead to replication fork stalling and can destabilize the genome. Both eukaryotic and prokaryotic cells possess resolution factors that reduce the severity of these encounters. Though Escherichia coli accessory helicases have been ...[more]
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