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Comprehensive transcriptome profiling reveals multigene signatures in triple negative breast cancer

ABSTRACT: To develop and validate novel multigene signatures to facilitate individualized treatment of TNBC patients By integrating expression profiles of messenger RNAs (mRNAs) and long non-coding RNAs (lncRNAs). We analysed 165 TNBC samples and 33 paired normal breast tissues using transcriptome microarrays. Tumor-specific mRNAs and lncRNAs were identified and correlated with patientsâ?? recurrence-free survival (RFS). Using Cox regression model, we built two multigene signatures incorporating mRNAs and lncRNAs. The prognostic and predictive accuracy of the signatures were tested in a training set of 165 TNBC patients and validated in another 101 TNBC patients.

ORGANISM(S): Homo sapiens

SUBMITTER: Yi-Zhou Jiang

PROVIDER: E-GEOD-76250 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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