Unknown,Transcriptomics,Genomics,Proteomics

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CXCR5+ Follicular Cytotoxic T cells Control Viral Infection in B Cell follicles

ABSTRACT: Lymphocytic Choriomeningitis Virus (LCMV) specific CD8+ T cells (P14) were transferred into congenic WT mice followed by LCMV(DOCILE) infection. CXCR5-expressing (CXCR5+) or CXCR5 non-expressing (CXCR5-) P14 were purified on day 8 after infection, and total mRNA were sequenced from these populations. mRNA of P14 from uninfected mice (Naive P14) was also sequenced. Examination of mRNA level in CXCR5 expressing P14 (CXCR5+P14) and non-expressing P14 (CXCR5-P14) from LCMV infected mice day 8 post infection. mRNA of P14 from uninfected mice (Naïve P14) was also examined.

ORGANISM(S): Mus musculus

SUBMITTER: Yew Ann Leong 

PROVIDER: E-GEOD-76279 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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CXCR5(+) follicular cytotoxic T cells control viral infection in B cell follicles.

Leong Yew Ann YA   Chen Yaping Y   Ong Hong Sheng HS   Wu Di D   Man Kevin K   Deleage Claire C   Minnich Martina M   Meckiff Benjamin J BJ   Wei Yunbo Y   Hou Zhaohua Z   Zotos Dimitra D   Fenix Kevin A KA   Atnerkar Anurag A   Preston Simon S   Chipman Jeffrey G JG   Beilman Greg J GJ   Allison Cody C CC   Sun Lei L   Wang Peng P   Xu Jiawei J   Toe Jesse G JG   Lu Hao K HK   Tao Yong Y   Palendira Umaimainthan U   Dent Alexander L AL   Landay Alan L AL   Pellegrini Marc M   Comerford Iain I   McColl Shaun R SR   Schacker Timothy W TW   Long Heather M HM   Estes Jacob D JD   Busslinger Meinrad M   Belz Gabrielle T GT   Lewin Sharon R SR   Kallies Axel A   Yu Di D  

Nature immunology 20160803 10

During unresolved infections, some viruses escape immunological control and establish a persistant reservoir in certain cell types, such as human immunodeficiency virus (HIV), which persists in follicular helper T cells (TFH cells), and Epstein-Barr virus (EBV), which persists in B cells. Here we identified a specialized group of cytotoxic T cells (TC cells) that expressed the chemokine receptor CXCR5, selectively entered B cell follicles and eradicated infected TFH cells and B cells. The differ  ...[more]

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