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Transcription profiling of human PBMC response to benzene metabolites


ABSTRACT: analyzed changes in cytokine/chemokine production and gene expression levels in, human peripheral blood mononuclear cells upon teratment with 15µM,2,4-benzenetriol Experiment Overall Design: Two groups of PBMC samples treated (Bt5) and nontreated (med); each group was biologically replicated 8 times.Total number of samples 16.

ORGANISM(S): Homo sapiens

SUBMITTER: Zarema Arbieva 

PROVIDER: E-GEOD-7664 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Identification of human cell responses to benzene and benzene metabolites.

Gillis Bruce B   Gavin Igor M IM   Arbieva Zarema Z   King Stephen T ST   Jayaraman Sundararajan S   Prabhakar Bellur S BS  

Genomics 20070615 3


Benzene is a common air pollutant and confirmed carcinogen, especially in reference to the hematopoietic system. In the present study we analyzed cytokine/chemokine production by, and gene expression induction in, human peripheral blood mononuclear cells upon their exposure to the benzene metabolites catechol, hydroquinone, 1,2,4-benzenetriol, and p-benzoquinone. Protein profiling showed that benzene metabolites can stimulate the production of chemokines, the proinflammatory cytokines TNF-alpha  ...[more]

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