Unknown,Transcriptomics,Genomics,Proteomics

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Tumour sampling method can significantly influence gene expression profiles derived from neoadjuvant window studies


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Dominic Pearce 

PROVIDER: E-GEOD-76728 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Tumour sampling method can significantly influence gene expression profiles derived from neoadjuvant window studies.

Pearce Dominic A DA   Arthur Laura M LM   Turnbull Arran K AK   Renshaw Lorna L   Sabine Vicky S VS   Thomas Jeremy S JS   Bartlett John M S JM   Dixon J Michael JM   Sims Andrew H AH  

Scientific reports 20160707


Patient-matched transcriptomic studies using tumour samples before and after treatment allow inter-patient heterogeneity to be controlled, but tend not to include an untreated comparison. Here, Illumina BeadArray technology was used to measure dynamic changes in gene expression from thirty-seven paired diagnostic core and surgically excised breast cancer biopsies obtained from women receiving no treatment prior to surgery, to determine the impact of sampling method and tumour heterogeneity. Desp  ...[more]

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