Distinct myeloid progenitor differentiation pathways uncovered through single cell RNA sequencing
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ABSTRACT: Haematopoietic stem cells can differentiate into all blood cell types. In this process, cells become progressively restricted to a single cell type. The order in which differentiating cells loose lineage potential, and the prospective isolation of cells with a defined potential remains a long-standing question. We performed gene expression analysis of haematopoietic cells from Gata1-EGFP reporter mice, leading to a model for hematopoiesis where the initial lineage decision consists of a seperation of erythroid/megakaryocyte/mast cell/eosinophil potential from lymphopoietic/monocyte/neutrophil potential Find unbiased heterogeneity in the preGM hematopoietic progenitor population
ORGANISM(S): Mus musculus
SUBMITTER: Supat Thongjuea
PROVIDER: E-GEOD-77029 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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