Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Jochen Wilhelm
PROVIDER: E-GEOD-77561 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
The Journal of infectious diseases 20160316 2
Streptococcus pneumoniae causes high mortality as a major pneumonia-inducing pathogen. In pneumonia, control of innate immunity is necessary to prevent organ damage. We assessed the role of microRNAs (miRNAs) as regulators in pneumococcal infection of human macrophages. Exposure of primary blood-derived human macrophages with pneumococci resulted in transcriptional changes in several gene clusters and a significant deregulation of 10 microRNAs. Computational network analysis retrieved miRNA-146a ...[more]