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RNA-Seq of Kidney Glomeruli from Type 2 diabetic (db/db) and non-diabetic mice

ABSTRACT: We investigated the gene expression profiles of RNA isolated from kidney glomeruli from aged, 25 week old type-2 diabetic (db/db) and non-diabetic mice. In order to investigate the consequences of hyperglycemia on the pathogenesis and progression of diabetic nephropathy Kidney glomeruli from 3 diabetic and 3 non-diabetic, control mice were isolated and RNA purified for RNA-Seq analysis on the Illumina HiSeq 2000. The goal of the project was to generate comprehensive list of noncoding RNA genes differentially regulated between the two conditions in order to identify novel targets for further study.

ORGANISM(S): Mus musculus

SUBMITTER: Shawn Badal 

PROVIDER: E-GEOD-77717 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Long noncoding RNA Tug1 regulates mitochondrial bioenergetics in diabetic nephropathy.

Long Jianyin J   Badal Shawn S SS   Ye Zengchun Z   Wang Yin Y   Ayanga Bernard A BA   Galvan Daniel L DL   Green Nathanael H NH   Chang Benny H BH   Overbeek Paul A PA   Danesh Farhad R FR  

The Journal of clinical investigation 20161017 11

The regulatory roles of long noncoding RNAs (lncRNAs) in transcriptional coactivators are still largely unknown. Here, we have shown that the peroxisome proliferator-activated receptor γ (PPARγ) coactivator α (PGC-1α, encoded by Ppargc1a) is functionally regulated by the lncRNA taurine-upregulated gene 1 (Tug1). Further, we have described a role for Tug1 in the regulation of mitochondrial function in podocytes. Using a murine model of diabetic nephropathy (DN), we performed an unbiased RNA-seque  ...[more]

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