Effects of aneuploidy on cellular physiology and cell division in haploid yeast.
Ontology highlight
ABSTRACT:
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: Maitreya Dunham
PROVIDER: E-GEOD-7812 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Effects of aneuploidy on cellular physiology and cell division in haploid yeast.
Torres Eduardo M EM Sokolsky Tanya T Tucker Cheryl M CM Chan Leon Y LY Boselli Monica M Dunham Maitreya J MJ Amon Angelika A
Science (New York, N.Y.) 20070801 5840
Aneuploidy is a condition frequently found in tumor cells, but its effect on cellular physiology is not known. We have characterized one aspect of aneuploidy: the gain of extra chromosomes. We created a collection of haploid yeast strains that each bear an extra copy of one or more of almost all of the yeast chromosomes. Their characterization revealed that aneuploid strains share a number of phenotypes, including defects in cell cycle progression, increased glucose uptake, and increased sensiti ...[more]
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